Manchester City will continue their assault on all four trophies this weekend when they turn their attention to the FA Cup, with a quarter-final place at stake.
The Premier League champions travel to Wales to play Newport County, the League Two club who are enjoying a stunning run in this season's competition.
While Monday's clash between Chelsea and Manchester United might be the heavyweight tie of the weekend, the meeting between lowly Newport and the might of City is the kind of contest the FA Cup has built its reputation on over the years.
Should Newport, who have already beaten Leicester and Middlesbrough to get to this stage, get a result against City, it would go down as one of the biggest shocks in the competition's history.
"It's a long shot, but I believe if we play to the best of our ability and they have a bit of an off day and miss a few chances then we can cause the biggest upset in the history of the FA Cup," said Newport manager Michael Flynn.
"I'm not unrealistic or delusional. I'm hoping they rest a few, I want a few of them to have a bad game and I want every single one of our players to play as well as they can, because that's the only chance we've got."
Chelsea and Manchester United meet at Old Trafford on Monday, with both looking to recover from defeats, albeit very different ones.
United were beaten 2-0 at home by Paris St Germain in the Champions League in midweek, while Chelsea were humbled 6-0 at Manchester City.
That defeat cast doubt on the future of Chelsea manager Mauricio Sarri but the Italian vowed to bounce back by taking out United, after a Thursday Europa League date in Sweden at Malmo.
"It's not easy to play after losing 6-0," Sarri admitted.
"But we have to play and we have to play well. We want to react immediately."
United could be without striker Anthony Martial and midfielder Jesse Lingard after both suffered injuries against PSG.
Meanwhile, Watford make the short journey to Queens Park Rangers on Friday night as the weekend's FA Cup action kicks off at Loftus Road.
Brighton & Hove Albion face Frank Lampard's Derby while Crystal Palace and Wolves, the other Premier League sides still in, are away to Doncaster and Bristol City respectively.
AFC Wimbledon face Millwall and Swansea meet Brentford in the other two fifth-round ties.